Holy Cross Lutheran Church was one of the first Lutheran congregations established in O'Fallon. After moving around to several different locations, including the VFW Hall and O'Fallon Mortuary Hall, the current church on Veterans Memorial Parkway was built in May 1975.
Holy Cross Lutheran participates in several community outreach programs, including providing support for the Hope Ministry Food Pantry and working with the O'Fallon Police Chaplains to provide assistance to those in temporary need of food, gas or utilities.