Roxborough is a neighborhood in the Northwest Philadelphia section of the United States city of Philadelphia, Pennsylvania. It is bordered to the southwest, along the Schuylkill River, by the neighborhood of Manayunk, along the northeast by the Wissahickon Creek section of Fairmount Park, and to the southeast by the neighborhood of East Falls. Beyond Roxbrough to the northwest is Montgomery County. Roxborough's zip code is 19128. Most of Roxborough is in Philadelphia's 21st Ward.
Most of modern day Roxborough was once part of Roxborough Township, which was incorporated into the City of Philadelphia following the passage of the Act of Consolidation, 1854.
Roxborough has been a predominantly white, middle class neighborhood of Philadelphia. Lower Roxborough and the Wissahickon section of the neighborhood, near East Falls, are working class. However, this economic picture is changing as gentrification occurs in Roxborough, Manayunk, and East Falls.