Patchogue-Medford High School, located on Buffalo Avenue, enrolls students from Patchogue and the surrounding communities. The school offers a wide range of educational programs, sports teams, and clubs, including AP courses and specialized programs. The school has an extensive roster of clubs, including the Book Club, Anti Bullying Club, Ecology Club, Math Team, Pay It Forward Club, Robotics, Venture Crew Club and Photo Club. Special courses offered include in European history and science, as well as in graphic design and website design. The school is part of the Patchogue-Medford school district and offers sports opportunities in baseball, track, Larosse, soccer and softball.