Hampton Inn & Suites St. Louis/South I-55 is Conveniently Located at I-55 & I-270 Interchange; 15 Minutes from Downtown St. Louis & The Gateway Arch. I-270 is The Major Beltway Around The City and Provides Quick Access to Illinois, West County, I-44, I-70, I-64/40 and Easy Driving to St. Louis’ Lambert Intl Airport. Each Of Our Beautifully Appointed Guest Rooms Are Non-Smoking and Feature All of The Conveniences Suited to The Savvy Business Traveler, Along With a Great Location and Recreational Amenities to Please Leisure Guests. Spacious Contemporary Guestrooms and Suites Boast a Long List of Guest Amenities Including: o