The Silberstein Laboratory, located in Boston, MA, is dedicated to researching the mechanisms that influence hematopoiesis in the bone marrow microenvironment. Their focus is on understanding the molecular signaling pathways of the CXCL12 CXCR4 chemokine axis and how it affects the localization and migration of hematopoietic progenitor cells. Through their research, they aim to improve stem progenitor cell engraftment following transplant.
Using both molecular and cellular approaches, as well as gene targeted animal models, the Silberstein Laboratory conducts research on human and murine cells to gain insights into the complex processes of hematopoiesis. Their ultimate goal is to devise strategies that enhance the engraftment and retention of stem progenitor cells in the bone marrow, leading to improved outcomes in hematopoietic development and transplantation.
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