The Isle Casino Hotel Bettendorf sits along the beautiful Mississippi River and proudly serves the Quad-Cities area. Sitting along the picturesque Mississippi River, proudly serving the Quad Cities area, our casino complex features nearly 1,000 of the latest slot machines. You can also try your luck at blackjack, craps, roulette, and electronic stadium gaming. After all the action, take some time to unwind in one of 500+ spacious rooms and suites.