Matlacha Isle Map
The City of Matlacha Isle is located in Lee County in the State of Florida. Find directions to Matlacha Isle, browse local businesses, landmarks, get current traffic estimates, road conditions, and more. The Matlacha Isle time zone is Eastern Daylight Time which is 5 hours behind Coordinated Universal Time (UTC).
Nearby cities include St. James City, Saint James City, Suncoast Estates, Bokeelia, Cape Coral.